Nurse burnout is a widespread phenomenon characterized by a reduction in nurses’ energy that manifests in emotional exhaustion, lack of motivation, and feelings of frustration and may lead to reductions in work efficacy. The nursing profession in India, as in other countries, is facing an increase in the annual turnover rate among Indian nurses as a result of labor migration, the low number of females selecting a nursing career and unattractive work conditions, which has led to a shortage of skilled and experienced nurses and a young nursing workforce. This review article primarily focuses on the challenges faced by the Indian nurses at their workplace. The nurses working in government hospitals exhibited the highest levels of stress and burnout compared with nurses who were working in teaching and private hospitals. Indeed, those three health sectors have been found to be different in terms of their organizational traits.